Two of the wounded were in a critical condition, NTV said. The assailant was caught, the local governor's office said.
"A report was received regarding gunfire in the vicinity of the Inci Uzmez Vocational and Technical Anatolian High School in our Turgutlu district at 07:59 (0459 GMT)," the office added on X.
Images and video posted online showed a male figure walking on a street near the school with a rifle in his hands. He was then seen running back from the same street.
The motive for the attack was not immediately clear.
Two deadly school shootings in April caused outrage in Turkey and prompted officials to bring innew security measures for the 2026-2027 academic year, including tighter gun controls.
Before then, the country had not had a history of such attacks.
Vice President Cevdet Yilmaz said Interior Minister Mustafa Ciftci and Education Minister Yusuf Tekin were going to Manisa to carry out inspections.
(Reporting by Tuvan Gumrukcu; Editing by Andrew Heavens)

Turkish security forces at the site of a shooting that took place in a school in Siverek district of Sanliurfa, Turkey, 14 April 2026. At least 16 people have been injured after a former student opened fire at the Ahmet Koyuncu Vocational and Technical Anatolian High School in Siverek district, before killing himself with the same weapon, according to governor Hasan Sildak. EPA/STRINGER
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